_power-up-crispri-amp-crispra-tools-for-genome-wide-screening.jpg "Power Up! CRISPRi & CRISPRa Tools for Genome-Wide Screening from dcas9 Video Screenshot Preview")
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⏲ Duration: 40 min 85 sec
✓ Published: 30-Oct-2017
✓ Published: 30-Oct-2017
Description:
Forward genetic screening with CRISPR-Cas9 has created remarkable new opportunities for biological discovery. The power of complete gene knockout in a pooled screening platform has delivered novel target ID, tackled complex mechanism of action, and driven the design of efficient and economical patient stratification for clinical studies. Using transcriptional regulation with catalytically-dead Cas9 (dCas9), both loss-of-function studies (CRISPR interference, CRISPRi) and gain-of-function studies
Forward genetic screening with CRISPR-Cas9 has created remarkable new opportunities for biological discovery. The power of complete gene knockout in a pooled screening platform has delivered novel target ID, tackled complex mechanism of action, and driven the design of efficient and economical patient stratification for clinical studies. Using transcriptional regulation with catalytically-dead Cas9 (dCas9), both loss-of-function studies (CRISPR interference, CRISPRi) and gain-of-function studies
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